Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_VJVDJABP

Embryonal tumors

f2bfba6e-98b5-5127-b136-392db86ae5eb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Embryonal tumors
cancer_type_detailed
subtype
cancer_type
Embryonal tumors
overall_survival_months
36.16951379763469
age_years
5.584
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.430
  • MYC_TARGETS_V2+0.404
  • OXIDATIVE_PHOSPHORYLATION+0.307
  • UNFOLDED_PROTEIN_RESPONSE+0.300
  • DNA_REPAIR+0.256
  • PROTEIN_SECRETION+0.247
  • PEROXISOME+0.159
  • WNT_BETA_CATENIN_SIGNALING+0.157
  • BILE_ACID_METABOLISM+0.096
  • HEME_METABOLISM+0.088

Top 10 suppressed

  • ANGIOGENESIS-0.565
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.551
  • IL6_JAK_STAT3_SIGNALING-0.500
  • ALLOGRAFT_REJECTION-0.482
  • INFLAMMATORY_RESPONSE-0.469
  • TNFA_SIGNALING_VIA_NFKB-0.449
  • COAGULATION-0.437
  • COMPLEMENT-0.400
  • INTERFERON_GAMMA_RESPONSE-0.388
  • HEDGEHOG_SIGNALING-0.334

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_K74PZET7
medullo-epn-umap@date-based
MedMedulloblastoma0.913
2R16
bladder-landscape@3
0.895
3s0095168
melanoma-umap@29
0.891
4SRR5088889
melanoma-umap@29
0.889
5BS_SDCNP7MW
brain-umap@2
Ependymoma NOS0.878
6BS_VA5T4KAA
brain-umap@2
medulloblastoma0.877
7TCGA-AR-A0TR-01A-11R-A084-07
breast-umap@18
B0.876
8DRR168565
bladder-landscape@3
0.876
9SRR1797243
lung-landscapes@6
cohortSC0.874
10AUR-AFKB-TTM1-A-1-1-R-A742-41
breast-umap@18
C0.873

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.430Inavolisib— uncovered
MYC_TARGETS_V20.404Idelalisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.307Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.300Idelalisib— uncovered
DNA_REPAIR0.256Idelalisib— uncovered
PROTEIN_SECRETION0.247Remibrutinib— uncovered
PEROXISOME0.159Idelalisib— uncovered
WNT_BETA_CATENIN_SIGNALING0.157Inavolisib— uncovered
BILE_ACID_METABOLISM0.096Inavolisib— uncovered
HEME_METABOLISM0.088Temsirolimus— uncovered
MTORC1_SIGNALING0.030Inavolisib— uncovered
SPERMATOGENESIS0.021Inavolisib— uncovered
ADIPOGENESIS0.001Inavolisib— uncovered