DRR168565

—

f9898590-dbad-5514-986e-a8c59746860a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —
sex: Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

MYC_TARGETS_V1+0.310
PROTEIN_SECRETION+0.310
OXIDATIVE_PHOSPHORYLATION+0.230
PEROXISOME+0.150
REACTIVE_OXYGEN_SPECIES_PATHWAY+0.080
MYC_TARGETS_V2+0.050
ADIPOGENESIS+0.010
FATTY_ACID_METABOLISM+0.010
ANDROGEN_RESPONSE+0.000
NOTCH_SIGNALING-0.010

Top 10 suppressed

IL6_JAK_STAT3_SIGNALING-0.480
TNFA_SIGNALING_VIA_NFKB-0.480
ANGIOGENESIS-0.470
INFLAMMATORY_RESPONSE-0.470
EPITHELIAL_MESENCHYMAL_TRANSITION-0.440
INTERFERON_ALPHA_RESPONSE-0.440
ALLOGRAFT_REJECTION-0.410
HYPOXIA-0.400
IL2_STAT5_SIGNALING-0.370
INTERFERON_GAMMA_RESPONSE-0.370

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant

#	Sample	Cancer type	Subtype	cos similarity
1	TCGA-A8-A08C-01A-11R-A00Z-07 breast-umap@18	—	B	0.931
2	SRR8943016 bladder-landscape@3	—	—	0.920
3	BS_SDCNP7MW medullo-epn-umap@date-based	EPN	EPN Tumor	0.907
4	MDT-AP-0395 medullo-epn-umap@date-based	Med	Medulloblastoma	0.900
5	s0095168 melanoma-umap@29	—	—	0.893
6	SRR23303735 bladder-landscape@3	—	—	0.891
7	BS_K74PZET7 medullo-epn-umap@date-based	Med	Medulloblastoma	0.890
8	SRR1387875 brain-umap@2	GTEX	—	0.887
9	MDT-AP-3207 medullo-epn-umap@date-based	Med	Medulloblastoma	0.884
10	SRR5088889 melanoma-umap@29	—	—	0.883

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 8 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
MYC_TARGETS_V1	0.310	Inavolisib	— uncovered
PROTEIN_SECRETION	0.310	Remibrutinib	— uncovered
OXIDATIVE_PHOSPHORYLATION	0.230	Remibrutinib	— uncovered
PEROXISOME	0.150	Idelalisib	— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY	0.080	Inavolisib	— uncovered
MYC_TARGETS_V2	0.050	Idelalisib	— uncovered
ADIPOGENESIS	0.010	Inavolisib	— uncovered
FATTY_ACID_METABOLISM	0.010	Inavolisib	— uncovered