Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR10900575

f3cf0abf-977b-52fb-a49e-901cb71736a8

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-50-6595-01A-12R-1858-07
lung-landscapes@6
cohortA10.929
2SRR934963
brain-umap@2
0.913
3TCGA-70-6722-01A-11R-1820-07
lung-landscapes@6
cohortSQ10.910
4BS_NR3P3GN2
brain-umap@2
high-grade glioma0.908
5SRR8942948
bladder-landscape@3
0.906
6BS_1AYRM596
medullo-epn-umap@date-based
MedMedulloblastoma0.901
7SRR934881
brain-umap@2
0.900
8TCGA-FD-A6TK-01A-42R-A33J-07
bladder-landscape@3
0.896
9AF0A7BAA-D031-4C9F-91B7-7034F2C49D72
brain-umap@2
0.896
10R409
bladder-landscape@3
0.895

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.600Remibrutinib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.600Inavolisib— uncovered
G2M_CHECKPOINT0.500Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.500Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.500Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.500Idelalisib— uncovered
TGF_BETA_SIGNALING0.500Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.500Inavolisib— uncovered
ALLOGRAFT_REJECTION0.400Idelalisib— uncovered
APICAL_JUNCTION0.400Inavolisib— uncovered
E2F_TARGETS0.400Inavolisib— uncovered
HEDGEHOG_SIGNALING0.400Inavolisib— uncovered
IL2_STAT5_SIGNALING0.400Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.400Inavolisib— uncovered
KRAS_SIGNALING_UP0.400Inavolisib— uncovered
MTORC1_SIGNALING0.400Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.400Idelalisib— uncovered
UV_RESPONSE_DN0.400Inavolisib— uncovered
ANDROGEN_RESPONSE0.300Inavolisib— uncovered
APOPTOSIS0.300Idelalisib— uncovered