AUR-AFR5-TTM1-A-1-1-R-A743-41
— · E
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- E
- subtype
- E
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_2Z1MKS84 | medulloblastoma | — | 0.923 |
| 2 | BS_VPBMDMQX | medulloblastoma | — | 0.920 |
| 3 | TCGA-37-A5EN-01A-21R-A26W-07 | — | cohortSQ2 | 0.917 |
| 4 | SJEPD001543_D1.RNA-Seq | EPN | Posterior Fossa EPN | 0.909 |
| 5 | TCGA-AN-A0AR-01A-11R-A00Z-07 | — | E | 0.909 |
| 6 | BS_DBEX7AG2 | Embryonal tumors | — | 0.908 |
| 7 | BS_HZRM07TW | medulloblastoma | — | 0.906 |
| 8 | BS_3V3KE3VT | medulloblastoma | — | 0.905 |
| 9 | TCGA-QK-A8Z7-01A-11R-A39I-07 | — | — | 0.904 |
| 10 | TCGA-46-6026-01A-11R-1820-07 | — | cohortSQ1 | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.520 | Idelalisib | — uncovered |
| E2F_TARGETS | 0.390 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.300 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.260 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.220 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.220 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.210 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.080 | Inavolisib | — uncovered |
| MYOGENESIS | 0.040 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.040 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.020 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.010 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.010 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.010 | Inavolisib | — uncovered |