SRR1432343
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.358
- SPERMATOGENESIS+0.334
- HEDGEHOG_SIGNALING+0.176
- MYOGENESIS+0.134
- PANCREAS_BETA_CELLS+0.020
- ESTROGEN_RESPONSE_LATE-0.027
- ESTROGEN_RESPONSE_EARLY-0.041
- UV_RESPONSE_DN-0.055
- APICAL_SURFACE-0.059
- BILE_ACID_METABOLISM-0.080
Top 10 suppressed
- MYC_TARGETS_V1-0.563
- INTERFERON_ALPHA_RESPONSE-0.514
- MTORC1_SIGNALING-0.489
- DNA_REPAIR-0.468
- E2F_TARGETS-0.460
- UNFOLDED_PROTEIN_RESPONSE-0.460
- PROTEIN_SECRETION-0.458
- INTERFERON_GAMMA_RESPONSE-0.454
- G2M_CHECKPOINT-0.435
- MYC_TARGETS_V2-0.427
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1406561 | GTEX | — | 0.988 |
| 2 | SRR1325986 | GTEX | — | 0.975 |
| 3 | SRR1385080 | GTEX | — | 0.972 |
| 4 | SRR602927 | GTEX | — | 0.970 |
| 5 | SRR1466850 | GTEX | — | 0.968 |
| 6 | SRR1336357 | GTEX | — | 0.967 |
| 7 | SRR1315269 | GTEX | — | 0.967 |
| 8 | SRR1403050 | GTEX | — | 0.967 |
| 9 | SRR1443824 | GTEX | — | 0.966 |
| 10 | SRR1335254 | GTEX | — | 0.965 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.358 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.334 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.176 | Inavolisib | — uncovered |
| MYOGENESIS | 0.134 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.020 | Cobimetinib | — uncovered |