AUR-AFSP-TTP1-A-8-0-R-A741-41
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.150
- KRAS_SIGNALING_DN+0.140
- ALLOGRAFT_REJECTION+0.110
- SPERMATOGENESIS+0.060
- INFLAMMATORY_RESPONSE+0.040
- IL6_JAK_STAT3_SIGNALING-0.010
- TNFA_SIGNALING_VIA_NFKB-0.060
- INTERFERON_GAMMA_RESPONSE-0.070
- PANCREAS_BETA_CELLS-0.070
- IL2_STAT5_SIGNALING-0.110
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.670
- MYC_TARGETS_V1-0.630
- PROTEIN_SECRETION-0.550
- MTORC1_SIGNALING-0.540
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.540
- CHOLESTEROL_HOMEOSTASIS-0.520
- UNFOLDED_PROTEIN_RESPONSE-0.520
- ADIPOGENESIS-0.490
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.490
- COAGULATION-0.480
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | AUR-AERW-TTP1-B-1-0-R-A741-41 | — | D | 0.933 |
| 2 | AUR-AD9G-TTP1-B-4-0-R-A584-39 | — | D | 0.920 |
| 3 | SRR8942981 | — | — | 0.914 |
| 4 | MNG83 | — | — | 0.907 |
| 5 | 20040121.LumB | — | D | 0.904 |
| 6 | SRR1446071 | GTEX | — | 0.904 |
| 7 | SRR1479912 | GTEX | — | 0.904 |
| 8 | MNG1217 | — | — | 0.904 |
| 9 | SRR11296732 | — | — | 0.903 |
| 10 | SRR11296796 | — | — | 0.901 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.150 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.140 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.110 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.040 | Idelalisib | — uncovered |