MNG83
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.128
- ALLOGRAFT_REJECTION+0.126
- KRAS_SIGNALING_DN+0.101
- SPERMATOGENESIS+0.099
- MITOTIC_SPINDLE+0.047
- APICAL_SURFACE+0.026
- INTERFERON_GAMMA_RESPONSE-0.021
- INFLAMMATORY_RESPONSE-0.024
- ANGIOGENESIS-0.027
- G2M_CHECKPOINT-0.052
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.524
- CHOLESTEROL_HOMEOSTASIS-0.494
- OXIDATIVE_PHOSPHORYLATION-0.466
- ADIPOGENESIS-0.433
- MTORC1_SIGNALING-0.420
- APOPTOSIS-0.394
- UNFOLDED_PROTEIN_RESPONSE-0.389
- GLYCOLYSIS-0.371
- HYPOXIA-0.370
- ESTROGEN_RESPONSE_LATE-0.367
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | AUR-AFSP-TTP1-A-8-0-R-A741-41 | — | D | 0.907 |
| 2 | SRR598533 | GTEX | — | 0.895 |
| 3 | SRR1485789 | GTEX | — | 0.889 |
| 4 | SRR934844 | — | — | 0.883 |
| 5 | AUR-AERW-TTP1-B-1-0-R-A741-41 | — | D | 0.882 |
| 6 | SRR934787 | — | — | 0.878 |
| 7 | SRR1452056 | GTEX | — | 0.876 |
| 8 | MNG959 | — | — | 0.875 |
| 9 | SRR934972 | — | — | 0.874 |
| 10 | SRR1479912 | GTEX | — | 0.874 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.128 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.126 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.101 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.099 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.047 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.026 | Temsirolimus | — uncovered |