SRR8942972
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.320
- INTERFERON_ALPHA_RESPONSE+0.270
- MITOTIC_SPINDLE+0.260
- PI3K_AKT_MTOR_SIGNALING+0.180
- E2F_TARGETS+0.160
- WNT_BETA_CATENIN_SIGNALING+0.150
- UV_RESPONSE_DN+0.140
- DNA_REPAIR+0.130
- G2M_CHECKPOINT+0.130
- INTERFERON_GAMMA_RESPONSE+0.110
Top 10 suppressed
- HYPOXIA-0.330
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.310
- KRAS_SIGNALING_DN-0.290
- TNFA_SIGNALING_VIA_NFKB-0.290
- ANGIOGENESIS-0.260
- CHOLESTEROL_HOMEOSTASIS-0.250
- ESTROGEN_RESPONSE_LATE-0.250
- MTORC1_SIGNALING-0.250
- OXIDATIVE_PHOSPHORYLATION-0.240
- SPERMATOGENESIS-0.230
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-3288 | Med | Medulloblastoma | 0.795 |
| 2 | SRR5088920 | — | — | 0.784 |
| 3 | TCGA-95-7947-01A-11R-2187-07 | — | cohortA1 | 0.780 |
| 4 | SJEPD031509_D1.RNA-Seq | EPN | Supratentorial EPN | 0.779 |
| 5 | MNG909 | — | — | 0.771 |
| 6 | SRR4195665 | — | — | 0.771 |
| 7 | MNG59 | — | — | 0.771 |
| 8 | C3N-03073 | — | cohortA1 | 0.768 |
| 9 | fe4a0710-a6db-4735-9d1a-113df310def6 | — | — | 0.767 |
| 10 | MNG388 | — | — | 0.766 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.320 | Remibrutinib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.270 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.260 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.180 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.160 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.150 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.140 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.130 | Idelalisib | — uncovered |
| G2M_CHECKPOINT | 0.130 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.110 | Idelalisib | — uncovered |
| PEROXISOME | 0.030 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.010 | Inavolisib | — uncovered |