Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_SDCNP7MW

EPN · EPN Tumor

b7a7fd60-a21c-5cbb-bb4f-056e0c910bf0

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
EPN
cancer_type_detailed
subtype
EPN Tumor
cancer_type
EPN
subtype
EPN Tumor
overall_survival_months
35.400000000000006
os_event
false
age_years
12.575
sex
M
race
White
e1_e2
E2
umap1_2d
-6.562638032
umap2_2d
1.160400712
umap1_3d
0.453357017
umap2_3d
4.028558139
umap3_3d
0.698062829
dataset
EPN-CBTN

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • MYC_TARGETS_V1+0.300
  • OXIDATIVE_PHOSPHORYLATION+0.260
  • SPERMATOGENESIS+0.150
  • DNA_REPAIR+0.140
  • PROTEIN_SECRETION+0.130
  • PEROXISOME+0.060
  • ADIPOGENESIS+0.020
  • BILE_ACID_METABOLISM+0.020
  • PANCREAS_BETA_CELLS-0.010
  • WNT_BETA_CATENIN_SIGNALING-0.010

Top 10 suppressed

  • ANGIOGENESIS-0.500
  • TNFA_SIGNALING_VIA_NFKB-0.470
  • HYPOXIA-0.450
  • INFLAMMATORY_RESPONSE-0.450
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.430
  • IL2_STAT5_SIGNALING-0.400
  • IL6_JAK_STAT3_SIGNALING-0.390
  • ALLOGRAFT_REJECTION-0.380
  • INTERFERON_GAMMA_RESPONSE-0.350
  • INTERFERON_ALPHA_RESPONSE-0.310

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_SDCNP7MW
brain-umap@2
Ependymoma NOS0.971
2DRR168565
bladder-landscape@3
0.907
3SRR1441118
brain-umap@2
GTEX0.900
4SRR1500537
brain-umap@2
GTEX0.899
5R16
bladder-landscape@3
0.897
6SRR1394450
brain-umap@2
GTEX0.894
7SRR1498702
brain-umap@2
GTEX0.893
8SRR1405224
brain-umap@2
GTEX0.893
9SRR1374246
brain-umap@2
GTEX0.890
10MDT-AP-0395
medullo-epn-umap@date-based
MedMedulloblastoma0.890

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 8 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
MYC_TARGETS_V10.300Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.260Remibrutinib— uncovered
SPERMATOGENESIS0.150Inavolisib— uncovered
DNA_REPAIR0.140Idelalisib— uncovered
PROTEIN_SECRETION0.130Remibrutinib— uncovered
PEROXISOME0.060Idelalisib— uncovered
ADIPOGENESIS0.020Inavolisib— uncovered
BILE_ACID_METABOLISM0.020Inavolisib— uncovered