Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-92-8064-01A-11R-2247-07

· cohortSQ2

f9ea81bc-056e-5d56-a5b0-10bf037f58cb

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortSQ2
subtype
cohortSQ2
age_years
58

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-77-8136-01A-11R-2247-07
lung-landscapes@6
cohortSQ10.882
2MNG1210
mng-umap@100
0.853
3TCGA-LC-A66R-01A-41R-A30C-07
bladder-landscape@3
0.848
4TCGA-A7-A4SD-01A-11R-A266-07
breast-umap@18
E0.829
5TCGA-XF-A9SM-01A-11R-A42T-07
bladder-landscape@3
0.826
6TCGA-A2-A0CM-01A-31R-A034-07
breast-umap@18
E0.824
7TCGA-FD-A3B3-01A-12R-A206-07
bladder-landscape@3
0.822
8TCGA-XF-A9SY-01A-21R-A42T-07
bladder-landscape@3
0.822
9SRR934956
brain-umap@2
0.820
10TCGA-CR-7373-01A-11R-2016-07
head-neck@1
0.819

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 34 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.610Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.580Idelalisib— uncovered
E2F_TARGETS0.540Inavolisib— uncovered
G2M_CHECKPOINT0.490Inavolisib— uncovered
ALLOGRAFT_REJECTION0.440Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.410Inavolisib— uncovered
MYC_TARGETS_V20.390Idelalisib— uncovered
MITOTIC_SPINDLE0.380Inavolisib— uncovered
APICAL_SURFACE0.350Temsirolimus— uncovered
UNFOLDED_PROTEIN_RESPONSE0.320Idelalisib— uncovered
INFLAMMATORY_RESPONSE0.300Idelalisib— uncovered
P53_PATHWAY0.300Idelalisib— uncovered
APOPTOSIS0.290Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.290Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.270Inavolisib— uncovered
DNA_REPAIR0.260Idelalisib— uncovered
HEDGEHOG_SIGNALING0.250Inavolisib— uncovered
COMPLEMENT0.240Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.240Inavolisib— uncovered
IL2_STAT5_SIGNALING0.230Idelalisib— uncovered