Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR13780252

· cohortMD2

fab2a92e-1bbe-5970-a74f-eb1713aecd63

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
cohortMD2
subtype
cohortMD2

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1ERR2598287
medullo-epn-umap@date-based
fetalfetal0.909
2TCGA-MT-A67F-01A-11R-A30B-07
head-neck@1
0.893
3BS_5AF6ZNJF
brain-umap@2
Meningioma0.883
4110682
medullo-epn-umap@date-based
EPNSupratentorial EPN0.882
5SJEPD032244_D1.RNA-Seq
medullo-epn-umap@date-based
EPNPosterior Fossa EPN0.881
6BS_55JW3HFM
brain-umap@2
Ganglioglioma0.874
7SRR608662
brain-umap@2
GTEX0.862
820060029.TNBC
breast-umap@18
D0.862
9BS_769BDPDB
brain-umap@2
pilocytic astrocytoma0.855
10ERR2208891
melanoma-umap@29
0.854

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 32 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
TNFA_SIGNALING_VIA_NFKB0.610Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.590Idelalisib— uncovered
ALLOGRAFT_REJECTION0.570Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.570Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.570Inavolisib— uncovered
COMPLEMENT0.550Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.520Idelalisib— uncovered
APOPTOSIS0.430Idelalisib— uncovered
IL2_STAT5_SIGNALING0.430Idelalisib— uncovered
TGF_BETA_SIGNALING0.380Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.370Inavolisib— uncovered
PANCREAS_BETA_CELLS0.310Cobimetinib— uncovered
P53_PATHWAY0.300Idelalisib— uncovered
COAGULATION0.290Binimetinib— uncovered
HYPOXIA0.290Idelalisib— uncovered
KRAS_SIGNALING_UP0.290Inavolisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.260Inavolisib— uncovered
HEME_METABOLISM0.250Temsirolimus— uncovered
UV_RESPONSE_UP0.250Idelalisib— uncovered
ANDROGEN_RESPONSE0.230Inavolisib— uncovered