SRR4195695
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.370
- PANCREAS_BETA_CELLS+0.290
- SPERMATOGENESIS+0.290
- MYOGENESIS+0.070
- APICAL_SURFACE-0.090
- E2F_TARGETS-0.100
- APICAL_JUNCTION-0.110
- CHOLESTEROL_HOMEOSTASIS-0.160
- G2M_CHECKPOINT-0.180
- DNA_REPAIR-0.200
Top 10 suppressed
- PROTEIN_SECRETION-0.620
- MYC_TARGETS_V1-0.550
- TGF_BETA_SIGNALING-0.540
- ANDROGEN_RESPONSE-0.490
- OXIDATIVE_PHOSPHORYLATION-0.480
- TNFA_SIGNALING_VIA_NFKB-0.450
- UV_RESPONSE_DN-0.450
- UNFOLDED_PROTEIN_RESPONSE-0.440
- KRAS_SIGNALING_UP-0.430
- MTORC1_SIGNALING-0.410
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR4195666 | — | — | 0.962 |
| 2 | SRR4195643 | — | — | 0.950 |
| 3 | SRR1452056 | GTEX | — | 0.947 |
| 4 | SRR1467813 | GTEX | — | 0.942 |
| 5 | BS_J71N7D09 | medulloblastoma | — | 0.938 |
| 6 | SRR1485789 | GTEX | — | 0.937 |
| 7 | SRR1797291 | — | cohortSC | 0.933 |
| 8 | SRR12696758 | — | — | 0.932 |
| 9 | TCGA-E7-A7PW-01A-11R-A352-07 | — | — | 0.931 |
| 10 | SRR13311179 | — | — | 0.931 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.370 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.290 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.290 | Inavolisib | — uncovered |
| MYOGENESIS | 0.070 | Inavolisib | — uncovered |