SRR12696758
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.200
- SPERMATOGENESIS+0.200
- PANCREAS_BETA_CELLS+0.100
- WNT_BETA_CATENIN_SIGNALING+0.000
- APICAL_SURFACE-0.100
- BILE_ACID_METABOLISM-0.100
- HEDGEHOG_SIGNALING-0.100
- MITOTIC_SPINDLE-0.100
- APICAL_JUNCTION-0.200
- E2F_TARGETS-0.200
Top 10 suppressed
- MYC_TARGETS_V1-0.600
- APOPTOSIS-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.500
- INTERFERON_ALPHA_RESPONSE-0.500
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.500
- ADIPOGENESIS-0.400
- ALLOGRAFT_REJECTION-0.400
- CHOLESTEROL_HOMEOSTASIS-0.400
- COAGULATION-0.400
- COMPLEMENT-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
4 twins match this tumor's tissue · 6 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12696768 | — | — | 0.973 |
| 2 | BS_4GTESTSE | Ganglioglioma | — | 0.967 |
| 3 | BS_J71N7D09 | medulloblastoma | — | 0.963 |
| 4 | SRR1455060 | GTEX | — | 0.959 |
| 5 | SRR4195666 | — | — | 0.953 |
| 6 | SRR627299 | GTEX | — | 0.951 |
| 7 | SRR1467813 | GTEX | — | 0.947 |
| 8 | SRR934787 | — | — | 0.947 |
| 9 | SRR26320081 | — | — | 0.946 |
| 10 | SRR1452056 | GTEX | — | 0.944 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 3 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.200 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.200 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.100 | Cobimetinib | — uncovered |