Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
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Quizartinib

5651eb7f-68e9-5f0b-a17d-9fb64ad801c5 · FDA Approved · targets FLT3

Quizartinib

MeasuredReference

Quizartinib targets FLT3, C_KIT, PDGFRB. Strongest hallmark effect: proliferation.

Primary targets

FLT3C_KITPDGFRBCSF1R

Top hallmarks

  • proliferation1.0k
  • evading apoptosis1.0k
  • tumor promoting inflammation840

Top pathways disrupted

  • apical junction2.5k
  • pi3k akt mtor signaling2.1k
  • apoptosis2.0k

Resistance landscape — Quizartinib

MeasuredReference

10 known oncogenic variants exist on Quizartinib's top targets — see detail for inhibition impact.

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