Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
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FLT3

RBC: FLT3 · Substrate: Abltide ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Gilteritinib99.20.51
Sunitinib98.70.52
Midostaurin98.60.50
Fedratinib98.20.58
Brigatinib98.10.51
Ponatinib97.90.53
Quizartinib97.90.74
Pralsetinib97.60.64
Sorafenib97.30.78
Fostamatinib97.20.61
Selpercatinib96.10.64
Entrectinib96.10.67
Nintedanib95.20.61
Cabozantinib95.00.75
Defactinib94.60.45

Known variants

Cancer associations

MutationCancer typeOrganSource
D835Yhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D835Ylymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D835YAML-USBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D835YLAML-KRBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D835YLAML-USBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D835YLAMLBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
E596INSEYAML-USBlood/Lymphatic Systemhttps://doi.org/10.1158/2159-8290.CD-12-0095
E596INSEYLAML-USBlood/Lymphatic Systemhttps://doi.org/10.1158/2159-8290.CD-12-0095
ITDAML-USBlood/Lymphatic Systemhttps://doi.org/10.1182/blood-2015-05-646240
ITDLAML-USBlood/Lymphatic Systemhttps://doi.org/10.1182/blood-2015-05-646241
R595INSRAML-USBlood/Lymphatic Systemhttps://www.cancer.gov/tcga.
R595INSRLAML-USBlood/Lymphatic Systemhttps://www.cancer.gov/tcga.
R595INSREYAML-USBlood/Lymphatic Systemhttps://depmap.org/portal.
R595INSREYLAML-USBlood/Lymphatic Systemhttps://depmap.org/portal.
V592INSVDFREYEYDAML-USBlood/Lymphatic Systemhttps://doi.org/10.1158/2159-8290.CD-12-0095
V592INSVDFREYEYDLAML-USBlood/Lymphatic Systemhttps://doi.org/10.1158/2159-8290.CD-12-0096
F594haematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
F594lymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
F691Lhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
R595haematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
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