KIRhub 2.0· v2

Alectinib

8280be0a-c782-5b42-b8ec-0a1fd0cb545b · FDA Approved · targets ALK, RET

Alectinib

MeasuredReference

Alectinib targets SRPK1, CAMK2D, MSSK1_STK23. Strongest hallmark effect: tumor promoting inflammation.

Primary targets

SRPK1 CAMK2D MSSK1_STK23 CHEK2 ALK

Top hallmarks

tumor promoting inflammation4.6k
proliferation4.0k
evading apoptosis3.9k

Top pathways disrupted

apical junction9.1k
pi3k akt mtor signaling8.9k
allograft rejection8.7k

Resistance landscape — Alectinib

MeasuredReference

10 known oncogenic variants exist on Alectinib's top targets — see detail for inhibition impact.

CHEK2 1 known variant
- CHK2 (I157T)
ALK 9 known variants

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