Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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ALK

RBC: ALK · Substrate: pEY ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Gilteritinib99.50.51
Repotrectinib99.40.61
Brigatinib99.20.51
Entrectinib98.80.67
Alectinib98.60.65
Ceritinib98.30.62
Crizotinib97.70.58
Lorlatinib97.20.69
Sunitinib87.70.52
Nintedanib84.90.61
Pralsetinib82.60.64
Alpelisib80.70.72
Osimertinib80.50.73
Bosutinib75.10.55
Pacritinib55.30.45

Known variants

Cancer associations

MutationCancer typeOrganSource
C1156Ycarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
D1203Ncarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
F1174LNeuroblastomaBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174Lneuroblastoma_autonomic_gangliaBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174Lmesothelioma_pleuraLunghttps://doi.org/10.1093/nar/gkaa945
F1174Lcarcinoma_kidneyKidneyhttps://doi.org/10.1093/nar/gkaa945
F1174Lcarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
F1174Lneuroblastic_tumour_autonomic_gangliaBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174Lcarcinoma_skinSkinhttps://doi.org/10.1093/nar/gkaa945
F1174Lganglioneuroblastoma_autonomic_gangliaBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174Linflammatory_myofibroblastic_tumour_soft_tissueSoft Tissuehttps://doi.org/10.1093/nar/gkaa945
F1174Lcarcinoma_salivary_glandSalivary Glandhttps://doi.org/10.1093/nar/gkaa945
F1174Lcarcinoma_prostateProstatehttps://doi.org/10.1093/nar/gkaa945
F1174LNBL-USBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174LNBBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174Sneuroblastoma_autonomic_gangliaBrain/CNShttps://doi.org/10.1093/nar/gkaa945
F1174Scarcinoma_endometriumUterushttps://doi.org/10.1093/nar/gkaa945
G1202Rcarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
G1202Rmalignant_melanoma_skinSkinhttps://doi.org/10.1093/nar/gkaa945
G1269Acarcinoma_lungLunghttps://doi.org/10.1093/nar/gkaa945
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