Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
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Avapritinib

b136f9e9-3784-576e-821d-8faaa613ff80 · FDA Approved · targets PDGFRA, PDGFRB

Avapritinib

MeasuredReference

Avapritinib targets PDGFRA, C_KIT, LIMK1. Strongest hallmark effect: tumor promoting inflammation.

Primary targets

PDGFRAC_KITLIMK1DDR1CSF1R

Top hallmarks

  • tumor promoting inflammation3.7k
  • proliferation3.0k
  • evading apoptosis2.8k

Top pathways disrupted

  • apical junction7.4k
  • allograft rejection6.9k
  • pi3k akt mtor signaling6.9k

Resistance landscape — Avapritinib

MeasuredReference

4 known oncogenic variants exist on Avapritinib's top targets — see detail for inhibition impact.

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