Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
Ependymoma Hub
V1V2
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PDGFRA

RBC: PDGFRa · Substrate: pEY + Mn ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Ponatinib100.00.53
Avapritinib99.10.64
Imatinib98.90.72
Dasatinib98.30.70
Nintedanib98.30.61
Nilotinib97.90.77
Tivozanib96.90.67
Regorafenib96.70.72
Axitinib96.00.69
Sorafenib95.60.78
Erdafitinib94.50.74
Midostaurin91.00.50
Capivasertib90.30.64
Lenvatinib88.00.73
Sunitinib84.20.52

Known variants

Cancer associations

MutationCancer typeOrganSource
D842Vgastrointestinal_stromal_tumour_soft_tissueSoft Tissuehttps://doi.org/10.1093/nar/gkaa945
D842Vcarcinoma_large_intestineLarge Intestinehttps://doi.org/10.1093/nar/gkaa945
D842Vother_stomachStomach/Digestive Tracthttps://doi.org/10.1093/nar/gkaa945
D842Vother_small_intestineSmall Intestinehttps://doi.org/10.1093/nar/gkaa945
D842Vglioma_central_nervous_systemBrain/CNShttps://doi.org/10.1093/nar/gkaa945
D842Vgastrointestinal_stromal_tumour_large_intestineLarge Intestinehttps://doi.org/10.1093/nar/gkaa945
D842Vother_large_intestineLarge Intestinehttps://doi.org/10.1093/nar/gkaa945
D842Vlymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D842Vother_gastrointestinal_tract_(site_indeterminate)Soft Tissuehttps://doi.org/10.1093/nar/gkaa945
D842Vhaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
D842Vcarcinoma_breastBreasthttps://doi.org/10.1093/nar/gkaa945
T674Icarcinoma_penisGenitourinary systemhttps://doi.org/10.1093/nar/gkaa945
T674Iadnexal_tumour_skinSkinhttps://doi.org/10.1093/nar/gkaa945
T674Ihaematopoietic_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
T674Icarcinoma_breastBreasthttps://doi.org/10.1093/nar/gkaa945
T674Icarcinoma_upper_aerodigestive_tractBrain/CNShttps://doi.org/10.1093/nar/gkaa945
V561Dgastrointestinal_stromal_tumour_soft_tissueSoft Tissuehttps://doi.org/10.1093/nar/gkaa945
V561Dother_stomachStomach/Digestive Tracthttps://doi.org/10.1093/nar/gkaa945
V561Dother_small_intestineSmall Intestinehttps://doi.org/10.1093/nar/gkaa945
G680Rgastrointestinal_stromal_tumour_soft_tissueSoft Tissuehttps://www.cancer.gov/tcga.
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