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RET-BCR

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BCR-RET · Variant type: fusion · Fusion partner: BCR

Drug response on this variant

#DrugInhibition on variantResidualKISS
1Pralsetinib100.0%0.0%93.43
2Selpercatinib99.4%0.6%96.72
3Fedratinib99.3%0.7%96.21
4Lenvatinib99.2%0.8%97.74
5Ponatinib99.1%0.9%78.23
6Regorafenib98.9%1.1%95.99
7Nintedanib98.9%1.1%90.23
8Alectinib98.8%1.2%95.49
9Entrectinib98.8%1.2%93.69
10Alpelisib98.6%1.4%97.22
11Tivozanib98.5%1.4%92.42
12Tenalisib97.7%2.3%97.98
13Brigatinib95.8%4.2%82.96
14Gilteritinib95.8%4.2%88.97
15Sorafenib95.5%4.5%96.72
16Cabozantinib94.8%5.2%92.73
17Futibatinib93.7%6.3%98.48
18Vandetanib91.4%8.6%95.74
19Sunitinib90.7%9.3%91.73
20Avapritinib86.4%13.6%97.73
21Axitinib84.9%15.1%93.23
22Ibrutinib78.8%21.2%94.74
23Fostamatinib78.1%21.9%96.74
24Erdafitinib77.2%22.8%95.71
25Ripretinib70.7%29.3%92.95

Wild-type vs variant — drug response delta

Positive Δ means the drug hits the variant harder than wild-type (mutation-selective); negative Δ means it loses potency (resistance).

DrugVariant inhWT inhΔ (variant − WT)
Pralsetinib100.0%
Selpercatinib99.4%
Fedratinib99.3%
Lenvatinib99.2%
Ponatinib99.1%
Regorafenib98.9%
Nintedanib98.9%
Alectinib98.8%
Entrectinib98.8%
Alpelisib98.6%
Tivozanib98.5%
Tenalisib97.7%
Brigatinib95.8%
Gilteritinib95.8%
Sorafenib95.5%
Cabozantinib94.8%
Futibatinib93.7%
Vandetanib91.4%
Sunitinib90.7%
Avapritinib86.4%
Axitinib84.9%
Ibrutinib78.8%
Fostamatinib78.1%
Erdafitinib77.2%
Ripretinib70.7%

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