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c-Src (T341M)

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SRC · Variant type: point · HGVS: p.T341M

Drug response on this variant

#DrugInhibition on variantResidualKISS
1Entrectinib99.9%0.1%93.69
2Repotrectinib99.4%0.6%84.21
3Pralsetinib99.3%0.7%93.43
4Crizotinib98.6%1.4%91.39
5Gilteritinib98.3%1.7%88.97
6Sunitinib97.5%2.5%91.73
7Brigatinib96.9%3.1%82.96
8Pacritinib96.6%3.4%88.64
9Defactinib95.7%4.3%92.68
10Fedratinib92.4%7.6%96.21
11Alpelisib92.0%8.0%97.22
12Selpercatinib91.1%8.9%96.72
13Bosutinib90.8%9.3%87.22
14Lorlatinib89.2%10.8%97.24
15Fostamatinib88.2%11.8%96.74
16Axitinib80.1%19.9%93.23
17Tenalisib77.6%22.4%97.98
18Nintedanib76.3%23.7%90.23
19Ponatinib61.4%38.6%78.23
20Deucravacitinib52.3%47.7%98.99
21Neratinib50.2%49.8%93.18
22Dasatinib48.9%51.1%87.97
23Futibatinib46.0%54.0%98.48
24Capivasertib41.5%58.5%96.48
25Upadacitinib40.7%59.3%97.98

Wild-type vs variant — drug response delta

Positive Δ means the drug hits the variant harder than wild-type (mutation-selective); negative Δ means it loses potency (resistance).

DrugVariant inhWT inhΔ (variant − WT)
Entrectinib99.9%
Repotrectinib99.4%
Pralsetinib99.3%
Crizotinib98.6%
Gilteritinib98.3%
Sunitinib97.5%
Brigatinib96.9%
Pacritinib96.6%
Defactinib95.7%
Fedratinib92.4%
Alpelisib92.0%
Selpercatinib91.1%
Bosutinib90.8%
Lorlatinib89.2%
Fostamatinib88.2%
Axitinib80.1%
Tenalisib77.6%
Nintedanib76.3%
Ponatinib61.4%
Deucravacitinib52.3%
Neratinib50.2%
Dasatinib48.9%
Futibatinib46.0%
Capivasertib41.5%
Upadacitinib40.7%

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