KIRhub 2.0
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Variant atlas

200 annotated variants across the profiled kinome. Each entry links to drug activity on-variant vs. wild-type.

P
116
Point
C
40
Compound
I
20
Indel
F
20
Fusion
U
4
Unknown
40 of 40 shown · clear type filter
ABL1 (Y245F/Y412F)
compoundp.Y245F;p.Y412F
ALK (I1171N/D1203N)
compoundp.I1171N;p.D1203N
ALK (L1196M/G1202R)
compoundp.L1196M;p.G1202R
BRAF (d485-489/P490Y)
compoundp.485_489del;p.P490Y
EGFR (C775S/T790M/L858R)
compoundp.C775S;p.T790M;p.L858R
EGFR (C797G/L858R)
compoundp.C797G;p.L858R
EGFR (C797S/L858R)
compoundp.C797S;p.L858R
EGFR (D770_N771insNPG/T790M)
compoundp.D770_N771insNPG;p.T790M
EGFR (K716A/C797S/L858R)
compoundp.K716A;p.C797S;p.L858R
EGFR (K716A/T790M/C797S/L858R)
compoundp.K716A;p.T790M;p.C797S;p.L858R
EGFR (K716Q/L718Q)
compoundp.K716Q;p.L718Q
EGFR (L792F/L858R)
compoundp.L792F;p.L858R
EGFR (L792H/C797S/L858R)
compoundp.L792H;p.C797S;p.L858R
EGFR (L792H/L858R)
compoundp.L792H;p.L858R
EGFR (T790M/C797G/L858R)
compoundp.746_750del;p.T790M;p.L858R
EGFR (T790M/C797S)
compoundp.T790M;p.C797S
EGFR (T790M/C797S/L858R)
compoundp.T790M;p.C797S;p.L858R
EGFR (T790M/L792F/C797S/L858R)
compoundp.T790M;p.L792F;p.C797S;p.L858R
EGFR (T790M/L792F/L858R)
compoundp.T790M;p.L792F;p.L858R
EGFR (T790M/L792H/C797S/L858R)
compoundp.T790M;p.L792H;p.C797S;p.L858R
EGFR (T790M/L792H/L858R)
compoundp.T790M;p.L792H;p.L858R
EGFR (T790M/L858R)
compoundp.T790M;p.L858R
EGFR (d746-750/C775S/T790M/L858R)
compoundp.746_750del;p.C775S;p.T790M;p.L858R
EGFR (d746-750/C797A)
compoundp.746_750del;p.C797A
EGFR (d746-750/C797S)
compoundp.746_750del;p.C797S
EGFR (d746-750/G724S)
compoundp.746_750del;p.G724S
EGFR (d746-750/S768I)
compoundp.746_750del;p.S768I
EGFR (d746-750/T790M/C797S)
compoundp.746_750del;p.T790M;p.C797S
EGFR (d746-750/T790M/C797S/L858R)
compoundp.746_750del;p.T790M;p.C797S;p.L858R
EGFR (d746-750/T790M/L792F)
compoundp.746_750del;p.T790M;p.L792F
EGFR (d746-750/T790M/L792H)
compoundp.746_750del;p.T790M;p.L792H
EGFR (d746-750/T790M/L798I)
compoundp.746_750del;p.T790M;p.L798I
EGFR (d746-750/T790M/L858R)
compoundp.746_750del;p.T790M;p.L858R
ERN1/IRE1 (R727A/R728A)
compoundp.R727A;p.R728A
FGFR2 (C491A/V564I)
compoundp.C491A;p.V564I
FGFR2 (C491A/V564L)
compoundp.C491A;p.V564L
FGFR2 (C491S/V564L)
compoundp.C491S;p.V564L
FLT3 (F691L/D835Y)
compoundp.F691L;p.D835Y
FLT3 (Y591-V592insVDFREYEYD/D835Y)
compoundp.Y591-V592insVDFREYEYD;p.D835Y
FLT3 (Y591-V592insVDFREYEYD/F691L)
compoundp.Y591-V592insVDFREYEYD;p.F691L