KIRhub 2.0
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Variant atlas

200 annotated variants across the profiled kinome. Each entry links to drug activity on-variant vs. wild-type.

P
116
Point
C
40
Compound
I
20
Indel
F
20
Fusion
U
4
Unknown
20 of 20 shown · clear type filter
ALK
fusionALK · partner NPM1
ALK (F1174L)-NPM1
fusionp.F1174L · partner NPM1 (F1174L)
PKN1-ANXA4 (Aex2Pex13)
fusionANXA4-PKN1 · partner ANXA4 (Aex2Pex13)
RET-BCR
fusionBCR-RET · partner BCR
RET-CCDC6 (PTC1)
fusionCCDC6-RET · partner CCDC6 (PTC1)
PKA-DNAJB1
fusionp.DNAJB1-PKA fusion · partner DNAJB1
ALK (F1174L)-EML4
fusionp.F1174L · partner EML4 (F1174L)
ALK-EML4 (Eex13Aex20)
fusionEML4-ALK · partner EML4 (Eex13Aex20)
EML4-ALK
fusionEML4-ALK · partner EML4 (Eex14Aex20)
BRAF-FAM131B (Fex2Bex9)
fusionFAM131B-BRAF · partner FAM131B (Fex2Bex9)
FGFR1OP-FGFR1
fusionFGFR1OP-FGFR1 · partner FGFR1
FLT3 (ITD)-NPOS
fusionp.L610_E611insCSSDNEYFYVDFREYEYDLKWEF-PRENL · partner NPOS (ITD)
FLT3 (ITD)-W51
fusionp.L601_K602insREYEYDL · partner W51 (ITD)
ROS1-GOPC
fusionGOPC-ROS1 · partner GOPC
BRAF-KIAA1549 (Kex15Bex9)
fusionKIAA1549-BRAF · partner KIAA1549 (Kex15Bex9)
BRAF-KIAA1549 (Kex16Bex9)
fusionKIAA1549-BRAF · partner KIAA1549 (Kex16Bex9)
KIF5B-ALK
fusionKIF5B-ALK · partner KIF5B (Kex24Aex20)
RET (V804L)-KIF5B
fusionp.Fusion;p.V804L · partner KIF5B (V804L)
RET (V804M)-KIF5B
fusionp.Fusion;p.V804M · partner KIF5B (V804M)
RET-KIF5B (Kex15Rex14)
fusionKIF5B-RET · partner KIF5B (Kex15Rex14)