Sorafenib — dose-response

MeasuredDerived

Dose-response curves across the assayed kinome. ← All drugs

Sorafenib × IRAK4

MeasuredDerived

IC50

0.23 nM

Hill slope

5.12

R²

0.4934

Top kinases by potency

MeasuredDerived

Ordered by IC50 ascending (fitted).

Kinase	IC50
IKBKB	0.07 nM
BMPR2	0.08 nM
TSSK2	0.09 nM
INSRR	0.14 nM
FER	0.14 nM
MAK	0.16 nM
MARK4	0.16 nM
IRAK4	0.23 nM
BRSK2	0.27 nM
CAMKK1	0.29 nM
CDK1+CCNA2	0.30 nM
MAPK3	0.30 nM
STK4	0.30 nM
PIM2	0.34 nM
PIM3	0.35 nM
MAP3K3	0.38 nM
PRKCB_1	0.55 nM
CSNK1G2	0.58 nM
SGK1	0.62 nM
PRKACB	0.68 nM
NEK7	0.71 nM
TSSK3	0.78 nM
PBK	0.79 nM
PRKCB_2	0.98 nM
RAF1	1.24 nM
DDR2	1.74 nM
BRSK1	1.74 nM
ZAP70	1.80 nM
MAPKAPK2	1.84 nM
PRKCH	1.87 nM