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CAMK1D(CAMK1d)

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UniProt Q8IU85 · PDB · AlphaFold · Substrate: Autocamtide 2 + Ca-CaM · Clone: full length

Top inhibitors

#DrugInhibitionResidualKISSGini
1Bosutinib83.2%16.8%87.220.555
2Brigatinib67.7%32.3%82.960.513
3Nintedanib64.6%35.4%90.230.608
4Pacritinib56.0%44.0%88.640.452
5Baricitinib48.8%51.2%97.990.616
6Gilteritinib42.3%57.7%88.970.506
7Midostaurin40.2%59.8%78.640.500
8Abemaciclib34.1%65.9%91.480.563
9Sunitinib33.4%66.6%91.730.524
10Dabrafenib33.1%66.9%94.740.633
11Pemigatinib31.8%68.2%98.230.718
12Ruxolitinib27.2%72.8%98.250.592
13Fedratinib24.2%75.8%96.210.576
14Alectinib23.3%76.7%95.490.651
15Infigratinib22.1%77.9%98.240.710
16Neratinib21.0%79.0%93.180.597
17Selpercatinib19.5%80.5%96.720.635
18Mobocertinib16.6%83.4%97.220.757
19Ceritinib16.2%83.8%95.440.618
20Lazertinib16.0%84.0%97.470.674

Paralog block

No paralog group registered for this kinase.

EMT expression

  • Mesenchymal log2(TPM+1): 1.91
  • Epithelial log2(TPM+1): 1.86
  • Fold change: 0.06
  • Status: No significant change

Selectivity landscape vs inhibition on CAMK1D

Each point is one of the 92 approved drugs; color = inhibition % on CAMK1D.

3D structure

Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.

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