CDK2/CCNE2(CDK2/cyclin E2)
Sign in to save this workspaceUniProt CDK2: P24941; cyclin E2: O96020 · PDB · AlphaFold (P24941), AlphaFold (O96020) · Substrate: RB Protein · Clone: full length / full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Defactinib | 89.9% | 10.1% | 92.68 | 0.450 |
| 2 | Abemaciclib | 62.8% | 37.2% | 91.48 | 0.563 |
| 3 | Pralsetinib | 53.6% | 46.4% | 93.43 | 0.643 |
| 4 | Vemurafenib | 34.2% | 65.8% | 96.49 | 0.598 |
| 5 | Pacritinib | 30.4% | 69.6% | 88.64 | 0.452 |
| 6 | Repotrectinib | 23.0% | 77.0% | 84.21 | 0.608 |
| 7 | Midostaurin | 19.0% | 81.0% | 78.64 | 0.500 |
| 8 | Neratinib | 18.4% | 81.6% | 93.18 | 0.597 |
| 9 | Gilteritinib | 16.7% | 83.3% | 88.97 | 0.506 |
| 10 | Pirtobrutinib | 14.7% | 85.3% | 99.49 | 0.656 |
| 11 | Palbociclib | 14.1% | 85.9% | 98.75 | 0.673 |
| 12 | Entrectinib | 13.2% | 86.8% | 93.69 | 0.671 |
| 13 | Brigatinib | 12.7% | 87.3% | 82.96 | 0.513 |
| 14 | Baricitinib | 11.7% | 88.3% | 97.99 | 0.616 |
| 15 | Lorlatinib | 11.2% | 88.8% | 97.24 | 0.694 |
| 16 | Alectinib | 10.6% | 89.4% | 95.49 | 0.651 |
| 17 | Sunitinib | 10.5% | 89.5% | 91.73 | 0.524 |
| 18 | Fostamatinib | 9.3% | 90.7% | 96.74 | 0.613 |
| 19 | Ibrutinib | 8.9% | 91.1% | 94.74 | 0.723 |
| 20 | Capmatinib | 8.8% | 91.2% | 99.75 | 0.582 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK2/CCNE2
Each point is one of the 92 approved drugs; color = inhibition % on CDK2/CCNE2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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