UniProt Q16832 · PDB · AlphaFold · Substrate: AXLtide + Mn · Clone: aa 422-855high-confidence target
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 100.0% | 0.0% | 78.23 | 0.534 |
| 2 | Nintedanib | 100.0% | 0.0% | 90.23 | 0.608 |
| 3 | Cabozantinib | 100.0% | 0.0% | 92.73 | 0.751 |
| 4 | Nilotinib | 99.7% | 0.3% | 96.49 | 0.765 |
| 5 | Dasatinib | 99.6% | 0.4% | 87.97 | 0.699 |
| 6 | Tivozanib | 99.3% | 0.7% | 92.42 | 0.673 |
| 7 | Vandetanib | 98.5% | 1.5% | 95.74 | 0.723 |
| 8 | Repotrectinib | 98.3% | 1.8% | 84.21 | 0.608 |
| 9 | Bosutinib | 97.6% | 2.4% | 87.22 | 0.555 |
| 10 | Regorafenib | 97.6% | 2.4% | 95.99 | 0.719 |
| 11 | Gilteritinib | 96.7% | 3.3% | 88.97 | 0.506 |
| 12 | Sorafenib | 96.3% | 3.7% | 96.72 | 0.776 |
| 13 | Pralsetinib | 95.9% | 4.1% | 93.43 | 0.643 |
| 14 | Dabrafenib | 95.4% | 4.6% | 94.74 | 0.633 |
| 15 | Ripretinib | 94.8% | 5.2% | 92.95 | 0.674 |
| 16 | Lenvatinib | 94.3% | 5.7% | 97.74 | 0.726 |
| 17 | Erdafitinib | 93.5% | 6.5% | 95.71 | 0.737 |
| 18 | Midostaurin | 92.5% | 7.5% | 78.64 | 0.500 |
| 19 | Selpercatinib | 92.2% | 7.8% | 96.72 | 0.635 |
| 20 | Vemurafenib | 89.4% | 10.6% | 96.49 | 0.598 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.62
- Epithelial log2(TPM+1): 0.94
- Fold change: 3.68
- Status: Upregulated
High-confidence drugs
- Nilotinib — inh 99.7% · KISS 51.08
- Imatinib — inh 87.7% · KISS 50.65
- Sorafenib — inh 96.3% · KISS 49.49
Selectivity landscape vs inhibition on DDR2
Each point is one of the 92 approved drugs; color = inhibition % on DDR2.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (2)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| T654M | carcinoma_lung | Lung | ref |
| N456S | carcinoma_lung | Lung | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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