MAP3K3(MEKK3)
Sign in to save this workspaceUniProt Q99759 · PDB · AlphaFold · Substrate: MBP · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 94.1% | 5.9% | 78.23 | 0.534 |
| 2 | Crizotinib | 90.3% | 9.8% | 91.39 | 0.581 |
| 3 | Bosutinib | 84.1% | 15.9% | 87.22 | 0.555 |
| 4 | Ripretinib | 81.5% | 18.5% | 92.95 | 0.674 |
| 5 | Midostaurin | 80.2% | 19.8% | 78.64 | 0.500 |
| 6 | Neratinib | 78.1% | 21.9% | 93.18 | 0.597 |
| 7 | Nintedanib | 76.4% | 23.6% | 90.23 | 0.608 |
| 8 | Repotrectinib | 63.3% | 36.7% | 84.21 | 0.608 |
| 9 | Infigratinib | 62.5% | 37.5% | 98.24 | 0.710 |
| 10 | Sunitinib | 61.2% | 38.8% | 91.73 | 0.524 |
| 11 | Dasatinib | 59.4% | 40.6% | 87.97 | 0.699 |
| 12 | Ruxolitinib | 57.0% | 43.0% | 98.25 | 0.592 |
| 13 | Baricitinib | 55.9% | 44.1% | 97.99 | 0.616 |
| 14 | Apatinib | 53.2% | 46.8% | 97.73 | 0.704 |
| 15 | Pemigatinib | 52.9% | 47.1% | 98.23 | 0.718 |
| 16 | Pacritinib | 33.0% | 67.0% | 88.64 | 0.452 |
| 17 | Brigatinib | 28.9% | 71.1% | 82.96 | 0.513 |
| 18 | Lorlatinib | 26.6% | 73.4% | 97.24 | 0.694 |
| 19 | Selumetinib | 26.3% | 73.7% | 100.00 | 0.640 |
| 20 | Pazopanib | 25.9% | 74.1% | 97.49 | 0.672 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.14
- Epithelial log2(TPM+1): 3.11
- Fold change: 1.03
- Status: Upregulated
Selectivity landscape vs inhibition on MAP3K3
Each point is one of the 92 approved drugs; color = inhibition % on MAP3K3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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