MAP3K6(MEKK6)
Sign in to save this workspaceUniProt O95382 · PDB · AlphaFold · Substrate: MBP · Clone: aa 620-950
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 38.6% | 61.4% | 78.23 | 0.534 |
| 2 | Dabrafenib | 23.3% | 76.7% | 94.74 | 0.633 |
| 3 | Umbralisib | 19.2% | 80.8% | 98.74 | 0.670 |
| 4 | Tucatinib | 17.6% | 82.4% | 99.75 | 0.652 |
| 5 | Mitapivat | 16.2% | 83.8% | 100.00 | 0.625 |
| 6 | Selumetinib | 15.9% | 84.1% | 100.00 | 0.640 |
| 7 | Abrocitinib | 15.0% | 85.0% | 99.50 | 0.581 |
| 8 | Tepotinib | 14.4% | 85.6% | 99.75 | 0.727 |
| 9 | Avapritinib | 13.3% | 86.7% | 97.73 | 0.644 |
| 10 | Brigatinib | 13.0% | 87.0% | 82.96 | 0.513 |
| 11 | Zanubrutinib | 12.2% | 87.8% | 98.24 | 0.788 |
| 12 | Netarsudil | 11.3% | 88.7% | 93.22 | 0.676 |
| 13 | Fedratinib | 11.0% | 89.0% | 96.21 | 0.576 |
| 14 | Alpelisib | 10.7% | 89.3% | 97.22 | 0.720 |
| 15 | Bosutinib | 10.3% | 89.7% | 87.22 | 0.555 |
| 16 | Regorafenib | 10.1% | 89.9% | 95.99 | 0.719 |
| 17 | Everolimus | 9.9% | 90.1% | 100.00 | 0.706 |
| 18 | Pazopanib | 9.4% | 90.6% | 97.49 | 0.672 |
| 19 | Apatinib | 9.3% | 90.7% | 97.73 | 0.704 |
| 20 | Baricitinib | 9.2% | 90.8% | 97.99 | 0.616 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 3.78
- Epithelial log2(TPM+1): 3.14
- Fold change: 0.65
- Status: No significant change
Selectivity landscape vs inhibition on MAP3K6
Each point is one of the 92 approved drugs; color = inhibition % on MAP3K6.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…