UniProt Q14680 · PDB · AlphaFold · Substrate: ZIPtide · Clone: aa 1-340medium-confidence target
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Nintedanib | 99.4% | 0.6% | 90.23 | 0.608 |
| 2 | Midostaurin | 94.9% | 5.1% | 78.64 | 0.500 |
| 3 | Sunitinib | 87.8% | 12.2% | 91.73 | 0.524 |
| 4 | Defactinib | 81.4% | 18.6% | 92.68 | 0.450 |
| 5 | Neratinib | 78.2% | 21.8% | 93.18 | 0.597 |
| 6 | Alectinib | 70.3% | 29.7% | 95.49 | 0.651 |
| 7 | Selpercatinib | 60.4% | 39.6% | 96.72 | 0.635 |
| 8 | Brigatinib | 51.4% | 48.6% | 82.96 | 0.513 |
| 9 | Tepotinib | 50.4% | 49.6% | 99.75 | 0.727 |
| 10 | Palbociclib | 46.6% | 53.4% | 98.75 | 0.673 |
| 11 | Gilteritinib | 44.6% | 55.4% | 88.97 | 0.506 |
| 12 | Dabrafenib | 42.7% | 57.3% | 94.74 | 0.633 |
| 13 | Fedratinib | 42.6% | 57.4% | 96.21 | 0.576 |
| 14 | Ponatinib | 40.0% | 60.0% | 78.23 | 0.534 |
| 15 | Gefitinib | 31.0% | 69.0% | 99.25 | 0.650 |
| 16 | Dacomitinib | 30.2% | 69.8% | 97.99 | 0.664 |
| 17 | Avapritinib | 28.3% | 71.7% | 97.73 | 0.644 |
| 18 | Ruxolitinib | 28.2% | 71.8% | 98.25 | 0.592 |
| 19 | Entrectinib | 23.5% | 76.5% | 93.69 | 0.671 |
| 20 | Pacritinib | 20.6% | 79.4% | 88.64 | 0.452 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.20
- Epithelial log2(TPM+1): 4.89
- Fold change: 0.31
- Status: No significant change
High-confidence drugs
- Nintedanib — inh 99.4% · KISS 36.77
- Midostaurin — inh 94.9% · KISS 24.80
- Sunitinib — inh 87.8% · KISS 21.45
Selectivity landscape vs inhibition on MELK
Each point is one of the 92 approved drugs; color = inhibition % on MELK.
Mutation lollipop
Cancer-associated mutations plotted by residue position. Marker size + color scale with the number of distinct cancer reports.
Variants (1)
Mutation × cancer associations
| Mutation | Cancer | Organ | Source |
|---|---|---|---|
| T460M | carcinoma_ovary | Ovary | ref |
| T460M | carcinoma_kidney | Kidney | ref |
| T460M | COREAD | Large Intestine | ref |
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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