UniProt O15146 · PDB · AlphaFold · Substrate: MBP + Mn · Clone: aa530-869high-confidence target
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 98.8% | 1.2% | 78.23 | 0.534 |
| 2 | Repotrectinib | 98.6% | 1.4% | 84.21 | 0.608 |
| 3 | Crizotinib | 97.7% | 2.3% | 91.39 | 0.581 |
| 4 | Entrectinib | 95.9% | 4.1% | 93.69 | 0.671 |
| 5 | Defactinib | 95.2% | 4.8% | 92.68 | 0.450 |
| 6 | Sorafenib | 92.0% | 8.0% | 96.72 | 0.776 |
| 7 | Fostamatinib | 90.8% | 9.3% | 96.74 | 0.613 |
| 8 | Cabozantinib | 89.6% | 10.4% | 92.73 | 0.751 |
| 9 | Sunitinib | 89.1% | 10.9% | 91.73 | 0.524 |
| 10 | Gilteritinib | 88.8% | 11.2% | 88.97 | 0.506 |
| 11 | Midostaurin | 88.0% | 12.0% | 78.64 | 0.500 |
| 12 | Fedratinib | 86.1% | 13.9% | 96.21 | 0.576 |
| 13 | Pralsetinib | 80.2% | 19.8% | 93.43 | 0.643 |
| 14 | Quizartinib | 79.2% | 20.8% | 99.50 | 0.737 |
| 15 | Regorafenib | 76.8% | 23.1% | 95.99 | 0.719 |
| 16 | Pacritinib | 73.3% | 26.7% | 88.64 | 0.452 |
| 17 | Axitinib | 73.2% | 26.8% | 93.23 | 0.688 |
| 18 | Alpelisib | 70.2% | 29.8% | 97.22 | 0.720 |
| 19 | Nintedanib | 67.9% | 32.1% | 90.23 | 0.608 |
| 20 | Nilotinib | 60.6% | 39.4% | 96.49 | 0.765 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.30
- Epithelial log2(TPM+1): 0.06
- Fold change: 0.24
- Status: No significant change
High-confidence drugs
- Sorafenib — inh 92.0% · KISS 44.42
- Quizartinib — inh 79.2% · KISS 42.19
- Entrectinib — inh 95.9% · KISS 40.29
Selectivity landscape vs inhibition on MUSK
Each point is one of the 92 approved drugs; color = inhibition % on MUSK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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