UniProt Q32MK0 · PDB · AlphaFold · Substrate: DAPK1tide + Ca-CaM · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Sunitinib | 84.9% | 15.1% | 91.73 | 0.524 |
| 2 | Pacritinib | 35.0% | 65.0% | 88.64 | 0.452 |
| 3 | Nintedanib | 25.4% | 74.6% | 90.23 | 0.608 |
| 4 | Defactinib | 25.3% | 74.7% | 92.68 | 0.450 |
| 5 | Quizartinib | 24.5% | 75.5% | 99.50 | 0.737 |
| 6 | Vemurafenib | 24.1% | 75.9% | 96.49 | 0.598 |
| 7 | Tivozanib | 20.2% | 79.8% | 92.42 | 0.673 |
| 8 | Pazopanib | 18.3% | 81.7% | 97.49 | 0.672 |
| 9 | Abemaciclib | 17.1% | 82.9% | 91.48 | 0.563 |
| 10 | Ripretinib | 15.6% | 84.4% | 92.95 | 0.674 |
| 11 | Mobocertinib | 14.0% | 86.0% | 97.22 | 0.757 |
| 12 | Selpercatinib | 13.8% | 86.2% | 96.72 | 0.635 |
| 13 | Pemigatinib | 12.2% | 87.8% | 98.23 | 0.718 |
| 14 | Imatinib | 10.8% | 89.2% | 99.00 | 0.718 |
| 15 | Bosutinib | 9.7% | 90.3% | 87.22 | 0.555 |
| 16 | Midostaurin | 8.3% | 91.7% | 78.64 | 0.500 |
| 17 | Pexidartinib | 7.8% | 92.2% | 99.49 | 0.631 |
| 18 | Fostamatinib | 7.8% | 92.2% | 96.74 | 0.613 |
| 19 | Pralsetinib | 7.4% | 92.6% | 93.43 | 0.643 |
| 20 | Ceritinib | 6.1% | 93.9% | 95.44 | 0.618 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.14
- Epithelial log2(TPM+1): 0.24
- Fold change: -0.11
- Status: No significant change
Selectivity landscape vs inhibition on MYLK3
Each point is one of the 92 approved drugs; color = inhibition % on MYLK3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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