UniProt Q96PY6 · PDB · AlphaFold · Substrate: MBP · Clone: aa 1-505
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 89.9% | 10.1% | 78.23 | 0.534 |
| 2 | Avapritinib | 78.7% | 21.3% | 97.73 | 0.644 |
| 3 | Dabrafenib | 67.3% | 32.7% | 94.74 | 0.633 |
| 4 | Erdafitinib | 65.3% | 34.7% | 95.71 | 0.737 |
| 5 | Defactinib | 59.9% | 40.1% | 92.68 | 0.450 |
| 6 | Pemigatinib | 59.0% | 41.0% | 98.23 | 0.718 |
| 7 | Fostamatinib | 42.6% | 57.4% | 96.74 | 0.613 |
| 8 | Repotrectinib | 40.7% | 59.3% | 84.21 | 0.608 |
| 9 | Neratinib | 32.7% | 67.3% | 93.18 | 0.597 |
| 10 | Crizotinib | 29.6% | 70.4% | 91.39 | 0.581 |
| 11 | Capivasertib | 22.9% | 77.1% | 96.48 | 0.644 |
| 12 | Pacritinib | 20.3% | 79.7% | 88.64 | 0.452 |
| 13 | Pazopanib | 20.0% | 80.0% | 97.49 | 0.672 |
| 14 | Fedratinib | 19.9% | 80.1% | 96.21 | 0.576 |
| 15 | Bosutinib | 19.8% | 80.2% | 87.22 | 0.555 |
| 16 | Midostaurin | 17.9% | 82.1% | 78.64 | 0.500 |
| 17 | Nintedanib | 15.6% | 84.4% | 90.23 | 0.608 |
| 18 | Gilteritinib | 15.1% | 84.9% | 88.97 | 0.506 |
| 19 | Baricitinib | 14.4% | 85.6% | 97.99 | 0.616 |
| 20 | Afatinib | 13.8% | 86.2% | 98.50 | 0.709 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.90
- Epithelial log2(TPM+1): 2.21
- Fold change: 0.69
- Status: No significant change
Selectivity landscape vs inhibition on NEK1
Each point is one of the 92 approved drugs; color = inhibition % on NEK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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