UniProt Q9HC98 · PDB · AlphaFold · Substrate: Casein · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Baricitinib | 10.8% | 89.2% | 97.99 | 0.616 |
| 2 | Dacomitinib | 10.6% | 89.4% | 97.99 | 0.664 |
| 3 | Ibrutinib | 9.8% | 90.2% | 94.74 | 0.723 |
| 4 | Midostaurin | 8.7% | 91.3% | 78.64 | 0.500 |
| 5 | Upadacitinib | 7.2% | 92.8% | 97.98 | 0.663 |
| 6 | Inavolisib | 6.8% | 93.2% | 100.00 | 0.679 |
| 7 | Mitapivat | 6.8% | 93.2% | 100.00 | 0.625 |
| 8 | Pralsetinib | 6.3% | 93.7% | 93.43 | 0.643 |
| 9 | Entrectinib | 6.0% | 94.0% | 93.69 | 0.671 |
| 10 | Binimetinib | 5.9% | 94.1% | 100.00 | 0.689 |
| 11 | Umbralisib | 5.6% | 94.4% | 98.74 | 0.670 |
| 12 | Lapatinib | 5.0% | 95.0% | 99.25 | 0.616 |
| 13 | Gedatolisib | 5.0% | 95.0% | 99.75 | 0.611 |
| 14 | Sorafenib | 4.8% | 95.2% | 96.72 | 0.776 |
| 15 | Defactinib | 4.2% | 95.8% | 92.68 | 0.450 |
| 16 | Nilotinib | 3.8% | 96.2% | 96.49 | 0.765 |
| 17 | Asciminib | 3.8% | 96.2% | 100.00 | 0.602 |
| 18 | Lazertinib | 3.8% | 96.2% | 97.47 | 0.674 |
| 19 | Netarsudil | 3.8% | 96.2% | 93.22 | 0.676 |
| 20 | Selpercatinib | 3.5% | 96.5% | 96.72 | 0.635 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.47
- Epithelial log2(TPM+1): 3.80
- Fold change: 1.67
- Status: Upregulated
Selectivity landscape vs inhibition on NEK6
Each point is one of the 92 approved drugs; color = inhibition % on NEK6.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…