UniProt Q8TDX7 · PDB · AlphaFold · Substrate: Casein · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Fostamatinib | 16.0% | 84.0% | 96.74 | 0.613 |
| 2 | Abrocitinib | 13.7% | 86.3% | 99.50 | 0.581 |
| 3 | Larotrectinib | 12.2% | 87.8% | 99.25 | 0.710 |
| 4 | Deucravacitinib | 11.9% | 88.1% | 98.99 | 0.718 |
| 5 | Dabrafenib | 9.8% | 90.2% | 94.74 | 0.633 |
| 6 | Selpercatinib | 9.5% | 90.5% | 96.72 | 0.635 |
| 7 | Tivozanib | 8.7% | 91.3% | 92.42 | 0.673 |
| 8 | Tucatinib | 8.0% | 92.0% | 99.75 | 0.652 |
| 9 | Vemurafenib | 7.7% | 92.3% | 96.49 | 0.598 |
| 10 | Pralsetinib | 6.8% | 93.2% | 93.43 | 0.643 |
| 11 | Lorlatinib | 6.8% | 93.2% | 97.24 | 0.694 |
| 12 | Pemigatinib | 6.8% | 93.3% | 98.23 | 0.718 |
| 13 | Entrectinib | 6.7% | 93.3% | 93.69 | 0.671 |
| 14 | Umbralisib | 6.5% | 93.5% | 98.74 | 0.670 |
| 15 | Encorafenib | 5.9% | 94.1% | 98.50 | 0.755 |
| 16 | Midostaurin | 5.8% | 94.2% | 78.64 | 0.500 |
| 17 | Defactinib | 5.7% | 94.3% | 92.68 | 0.450 |
| 18 | Alectinib | 5.6% | 94.4% | 95.49 | 0.651 |
| 19 | Erdafitinib | 5.5% | 94.5% | 95.71 | 0.737 |
| 20 | Alpelisib | 5.4% | 94.6% | 97.22 | 0.720 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.55
- Epithelial log2(TPM+1): 4.01
- Fold change: 1.54
- Status: Upregulated
Selectivity landscape vs inhibition on NEK7
Each point is one of the 92 approved drugs; color = inhibition % on NEK7.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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