UniProt Q13153 · PDB · AlphaFold · Substrate: PAKtide · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Neratinib | 82.2% | 17.9% | 93.18 | 0.597 |
| 2 | Midostaurin | 43.5% | 56.5% | 78.64 | 0.500 |
| 3 | Pralsetinib | 33.1% | 66.9% | 93.43 | 0.643 |
| 4 | Fostamatinib | 25.0% | 75.0% | 96.74 | 0.613 |
| 5 | Defactinib | 23.9% | 76.1% | 92.68 | 0.450 |
| 6 | Pacritinib | 22.1% | 77.9% | 88.64 | 0.452 |
| 7 | Bosutinib | 17.6% | 82.4% | 87.22 | 0.555 |
| 8 | Ibrutinib | 14.8% | 85.2% | 94.74 | 0.723 |
| 9 | Brigatinib | 12.1% | 87.9% | 82.96 | 0.513 |
| 10 | Pirtobrutinib | 10.9% | 89.1% | 99.49 | 0.656 |
| 11 | Vemurafenib | 10.1% | 89.9% | 96.49 | 0.598 |
| 12 | Tenalisib | 10.0% | 90.0% | 97.98 | 0.702 |
| 13 | Pazopanib | 9.4% | 90.6% | 97.49 | 0.672 |
| 14 | Gedatolisib | 9.2% | 90.8% | 99.75 | 0.611 |
| 15 | Osimertinib | 7.4% | 92.6% | 97.24 | 0.733 |
| 16 | Ribociclib | 7.0% | 93.0% | 99.25 | 0.729 |
| 17 | Leniolisib | 6.8% | 93.2% | 100.00 | 0.604 |
| 18 | Alpelisib | 6.7% | 93.3% | 97.22 | 0.720 |
| 19 | Netarsudil | 6.6% | 93.4% | 93.22 | 0.676 |
| 20 | Apatinib | 6.4% | 93.6% | 97.73 | 0.704 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.65
- Epithelial log2(TPM+1): 4.74
- Fold change: -0.09
- Status: No significant change
Selectivity landscape vs inhibition on PAK1
Each point is one of the 92 approved drugs; color = inhibition % on PAK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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