UniProt P53350 · PDB · AlphaFold · Substrate: Casein · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Brigatinib | 58.8% | 41.2% | 82.96 | 0.513 |
| 2 | Defactinib | 48.9% | 51.1% | 92.68 | 0.450 |
| 3 | Palbociclib | 38.9% | 61.1% | 98.75 | 0.673 |
| 4 | Ceritinib | 35.9% | 64.1% | 95.44 | 0.618 |
| 5 | Fedratinib | 20.2% | 79.8% | 96.21 | 0.576 |
| 6 | Pacritinib | 14.8% | 85.2% | 88.64 | 0.452 |
| 7 | Canertinib | 14.1% | 85.9% | 96.49 | 0.671 |
| 8 | Ruxolitinib | 12.7% | 87.3% | 98.25 | 0.592 |
| 9 | Abrocitinib | 12.6% | 87.4% | 99.50 | 0.581 |
| 10 | Bosutinib | 12.3% | 87.7% | 87.22 | 0.555 |
| 11 | Abemaciclib | 10.7% | 89.3% | 91.48 | 0.563 |
| 12 | Midostaurin | 10.5% | 89.5% | 78.64 | 0.500 |
| 13 | Alectinib | 10.4% | 89.6% | 95.49 | 0.651 |
| 14 | Fostamatinib | 10.2% | 89.8% | 96.74 | 0.613 |
| 15 | Tucatinib | 8.7% | 91.3% | 99.75 | 0.652 |
| 16 | Quizartinib | 8.4% | 91.6% | 99.50 | 0.737 |
| 17 | Avapritinib | 8.1% | 91.9% | 97.73 | 0.644 |
| 18 | Mitapivat | 7.9% | 92.1% | 100.00 | 0.625 |
| 19 | Umbralisib | 7.7% | 92.3% | 98.74 | 0.670 |
| 20 | Sunitinib | 7.6% | 92.4% | 91.73 | 0.524 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 5.66
- Epithelial log2(TPM+1): 5.70
- Fold change: -0.04
- Status: No significant change
Selectivity landscape vs inhibition on PLK1
Each point is one of the 92 approved drugs; color = inhibition % on PLK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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