UniProt P51817 · PDB · AlphaFold · Substrate: Kemptide · Clone: full lengthhigh-confidence target
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Capivasertib | 98.3% | 1.7% | 96.48 | 0.644 |
| 2 | Netarsudil | 98.3% | 1.7% | 93.22 | 0.676 |
| 3 | Midostaurin | 86.1% | 13.9% | 78.64 | 0.500 |
| 4 | Baricitinib | 60.2% | 39.8% | 97.99 | 0.616 |
| 5 | Defactinib | 53.5% | 46.5% | 92.68 | 0.450 |
| 6 | Selpercatinib | 40.6% | 59.4% | 96.72 | 0.635 |
| 7 | Avapritinib | 28.5% | 71.5% | 97.73 | 0.644 |
| 8 | Ponatinib | 25.7% | 74.3% | 78.23 | 0.534 |
| 9 | Ruxolitinib | 23.8% | 76.2% | 98.25 | 0.592 |
| 10 | Pexidartinib | 22.8% | 77.2% | 99.49 | 0.631 |
| 11 | Selumetinib | 20.0% | 80.0% | 100.00 | 0.640 |
| 12 | Sunitinib | 19.8% | 80.2% | 91.73 | 0.524 |
| 13 | Pacritinib | 16.1% | 83.9% | 88.64 | 0.452 |
| 14 | Paxalisib | 14.2% | 85.8% | 99.75 | 0.609 |
| 15 | Apatinib | 13.4% | 86.6% | 97.73 | 0.704 |
| 16 | Umbralisib | 12.8% | 87.3% | 98.74 | 0.670 |
| 17 | Leniolisib | 10.8% | 89.2% | 100.00 | 0.604 |
| 18 | Ceritinib | 10.8% | 89.2% | 95.44 | 0.618 |
| 19 | Upadacitinib | 10.8% | 89.3% | 97.98 | 0.663 |
| 20 | Imatinib | 10.4% | 89.6% | 99.00 | 0.718 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 2.54
- Epithelial log2(TPM+1): 3.13
- Fold change: -0.59
- Status: No significant change
High-confidence drugs
- Netarsudil — inh 98.3% · KISS 41.58
- Midostaurin — inh 86.1% · KISS 15.61
- Baricitinib — inh 60.2% · KISS 2.79
Selectivity landscape vs inhibition on PRKX
Each point is one of the 92 approved drugs; color = inhibition % on PRKX.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
Sign in to read and post annotations.
Loading…