NTRK1(TRKA)
Sign in to save this workspaceUniProt P04629 · PDB · AlphaFold · Substrate: pEY + Mn · Clone: Cytoplasmic (441-796)
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Entrectinib | 99.0% | 1.0% | 93.69 | 0.671 |
| 2 | Repotrectinib | 98.9% | 1.1% | 84.21 | 0.608 |
| 3 | Pralsetinib | 98.7% | 1.3% | 93.43 | 0.643 |
| 4 | Larotrectinib | 98.5% | 1.5% | 99.25 | 0.710 |
| 5 | Ponatinib | 98.4% | 1.6% | 78.23 | 0.534 |
| 6 | Alpelisib | 97.5% | 2.5% | 97.22 | 0.720 |
| 7 | Crizotinib | 95.8% | 4.2% | 91.39 | 0.581 |
| 8 | Nintedanib | 93.8% | 6.2% | 90.23 | 0.608 |
| 9 | Midostaurin | 93.7% | 6.3% | 78.64 | 0.500 |
| 10 | Ripretinib | 93.6% | 6.4% | 92.95 | 0.674 |
| 11 | Cabozantinib | 93.6% | 6.4% | 92.73 | 0.751 |
| 12 | Gilteritinib | 92.6% | 7.4% | 88.97 | 0.506 |
| 13 | Pacritinib | 89.4% | 10.6% | 88.64 | 0.452 |
| 14 | Tivozanib | 85.7% | 14.3% | 92.42 | 0.673 |
| 15 | Sunitinib | 82.8% | 17.2% | 91.73 | 0.524 |
| 16 | Defactinib | 80.3% | 19.7% | 92.68 | 0.450 |
| 17 | Bosutinib | 67.0% | 33.0% | 87.22 | 0.555 |
| 18 | Lorlatinib | 63.2% | 36.8% | 97.24 | 0.694 |
| 19 | Tenalisib | 59.0% | 41.0% | 97.98 | 0.702 |
| 20 | Fedratinib | 56.2% | 43.8% | 96.21 | 0.576 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.25
- Epithelial log2(TPM+1): 0.39
- Fold change: -0.14
- Status: No significant change
Selectivity landscape vs inhibition on NTRK1
Each point is one of the 92 approved drugs; color = inhibition % on NTRK1.
Variants (13)
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
Annotations
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