UniProt P42681 · PDB · AlphaFold · Substrate: ABLtide · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Canertinib | 100.0% | 0.0% | 96.49 | 0.671 |
| 2 | Ibrutinib | 99.9% | 0.1% | 94.74 | 0.723 |
| 3 | Repotrectinib | 99.8% | 0.2% | 84.21 | 0.608 |
| 4 | Dasatinib | 99.1% | 0.9% | 87.97 | 0.699 |
| 5 | Entrectinib | 99.1% | 0.9% | 93.69 | 0.671 |
| 6 | Dacomitinib | 97.9% | 2.1% | 97.99 | 0.664 |
| 7 | Osimertinib | 97.6% | 2.4% | 97.24 | 0.733 |
| 8 | Bosutinib | 97.2% | 2.8% | 87.22 | 0.555 |
| 9 | Mobocertinib | 97.1% | 2.9% | 97.22 | 0.757 |
| 10 | Lazertinib | 97.0% | 3.0% | 97.47 | 0.674 |
| 11 | Zanubrutinib | 96.9% | 3.1% | 98.24 | 0.788 |
| 12 | Ponatinib | 95.3% | 4.7% | 78.23 | 0.534 |
| 13 | Afatinib | 93.0% | 7.0% | 98.50 | 0.709 |
| 14 | Nintedanib | 90.7% | 9.3% | 90.23 | 0.608 |
| 15 | Pralsetinib | 87.8% | 12.2% | 93.43 | 0.643 |
| 16 | Gilteritinib | 86.8% | 13.2% | 88.97 | 0.506 |
| 17 | Brigatinib | 86.5% | 13.5% | 82.96 | 0.513 |
| 18 | Pacritinib | 85.7% | 14.3% | 88.64 | 0.452 |
| 19 | Alpelisib | 80.0% | 20.0% | 97.22 | 0.720 |
| 20 | Pazopanib | 79.0% | 21.0% | 97.49 | 0.672 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 0.65
- Epithelial log2(TPM+1): 0.64
- Fold change: 0.01
- Status: No significant change
Selectivity landscape vs inhibition on TXK
Each point is one of the 92 approved drugs; color = inhibition % on TXK.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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