UniProt Q99986 · PDB · AlphaFold · Substrate: Long S6 Kinase substrate peptide · Clone: full length, Met1-Lys396
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Pacritinib | 53.7% | 46.3% | 88.64 | 0.452 |
| 2 | Capivasertib | 25.2% | 74.8% | 96.48 | 0.644 |
| 3 | Duvelisib | 24.2% | 75.8% | 100.00 | 0.716 |
| 4 | Dabrafenib | 24.0% | 76.0% | 94.74 | 0.633 |
| 5 | Encorafenib | 23.5% | 76.5% | 98.50 | 0.755 |
| 6 | Abrocitinib | 22.7% | 77.3% | 99.50 | 0.581 |
| 7 | Baricitinib | 20.7% | 79.3% | 97.99 | 0.616 |
| 8 | Pazopanib | 20.5% | 79.5% | 97.49 | 0.672 |
| 9 | Avapritinib | 20.4% | 79.6% | 97.73 | 0.644 |
| 10 | Dacomitinib | 20.3% | 79.7% | 97.99 | 0.664 |
| 11 | Osimertinib | 20.1% | 79.9% | 97.24 | 0.733 |
| 12 | Tofacitinib | 19.7% | 80.3% | 99.25 | 0.684 |
| 13 | Fedratinib | 19.5% | 80.5% | 96.21 | 0.576 |
| 14 | Tepotinib | 18.6% | 81.4% | 99.75 | 0.727 |
| 15 | Mitapivat | 17.5% | 82.5% | 100.00 | 0.625 |
| 16 | Ibrutinib | 16.8% | 83.2% | 94.74 | 0.723 |
| 17 | Darovasertib | 16.8% | 83.2% | 96.99 | 0.719 |
| 18 | Abemaciclib | 16.6% | 83.4% | 91.48 | 0.563 |
| 19 | Repotrectinib | 16.1% | 83.9% | 84.21 | 0.608 |
| 20 | Ribociclib | 15.6% | 84.4% | 99.25 | 0.729 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 4.62
- Epithelial log2(TPM+1): 5.08
- Fold change: -0.46
- Status: No significant change
Selectivity landscape vs inhibition on VRK1
Each point is one of the 92 approved drugs; color = inhibition % on VRK1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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