Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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725c9ca0-31db-4dda-ac6d-9be7565e7cfe

0071adec-7caf-5f4a-8f01-04ffa86d962a

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
age_years
60

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • CHOLESTEROL_HOMEOSTASIS+0.310
  • PEROXISOME+0.220
  • TGF_BETA_SIGNALING+0.180
  • OXIDATIVE_PHOSPHORYLATION+0.170
  • BILE_ACID_METABOLISM+0.130
  • HEDGEHOG_SIGNALING+0.100
  • FATTY_ACID_METABOLISM+0.080
  • DNA_REPAIR+0.050
  • P53_PATHWAY+0.030
  • APICAL_SURFACE-0.010

Top 10 suppressed

  • ALLOGRAFT_REJECTION-0.510
  • INFLAMMATORY_RESPONSE-0.490
  • INTERFERON_GAMMA_RESPONSE-0.460
  • IL6_JAK_STAT3_SIGNALING-0.440
  • COMPLEMENT-0.380
  • IL2_STAT5_SIGNALING-0.370
  • ESTROGEN_RESPONSE_EARLY-0.270
  • HYPOXIA-0.270
  • KRAS_SIGNALING_UP-0.260
  • TNFA_SIGNALING_VIA_NFKB-0.250

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
18fba9293-e3f1-41ef-b79e-499a02826174
colon-landscapes@1
0.829
2MBCProject_0004_T1_RNA
breast-umap@18
C0.791
3d14f7871-db2f-423a-9e08-4ca84e452d61
melanoma-umap@29
0.790
4SRR8943016
bladder-landscape@3
0.775
5R230
bladder-landscape@3
0.771
6TCGA-ZF-A9RL-01A-11R-A38B-07
bladder-landscape@3
0.767
7SRR8518328
breast-umap@18
C0.763
8SRR8613720
breast-umap@18
C0.763
968fda9a5-c6eb-4445-91f7-bd0078080b9d
colon-landscapes@1
0.762
10TCGA-S3-AA11-01A-31R-A41B-07
breast-umap@18
B0.761