8fba9293-e3f1-41ef-b79e-499a02826174
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 75
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.380
- WNT_BETA_CATENIN_SIGNALING+0.300
- FATTY_ACID_METABOLISM+0.210
- CHOLESTEROL_HOMEOSTASIS+0.170
- PEROXISOME+0.140
- BILE_ACID_METABOLISM+0.130
- HEDGEHOG_SIGNALING+0.110
- ADIPOGENESIS+0.090
- TGF_BETA_SIGNALING+0.080
- KRAS_SIGNALING_DN+0.070
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.560
- INTERFERON_GAMMA_RESPONSE-0.540
- IL6_JAK_STAT3_SIGNALING-0.470
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.460
- INFLAMMATORY_RESPONSE-0.440
- TNFA_SIGNALING_VIA_NFKB-0.420
- ALLOGRAFT_REJECTION-0.410
- COMPLEMENT-0.410
- E2F_TARGETS-0.390
- G2M_CHECKPOINT-0.360
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | 68fda9a5-c6eb-4445-91f7-bd0078080b9d | — | — | 0.901 |
| 2 | MBCProject_0004_T1_RNA | — | C | 0.847 |
| 3 | SRR25617889 | — | B | 0.838 |
| 4 | TCGA-CN-6992-01A-11R-1915-07 | — | — | 0.836 |
| 5 | SRR35579848 | — | B | 0.835 |
| 6 | SRR650196 | — | — | 0.833 |
| 7 | MBCProject_0343_T1_RNA | — | B | 0.831 |
| 8 | 725c9ca0-31db-4dda-ac6d-9be7565e7cfe | — | — | 0.829 |
| 9 | SRR1072504 | GTEX | — | 0.827 |
| 10 | SRR8518272 | — | E | 0.825 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.380 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.300 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.210 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.170 | Remibrutinib | — uncovered |
| PEROXISOME | 0.140 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.110 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.090 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.080 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.070 | Remibrutinib | — uncovered |
| APICAL_SURFACE | 0.060 | Temsirolimus | — uncovered |
| PROTEIN_SECRETION | 0.040 | Remibrutinib | — uncovered |