BSR_16_0051_A2_S82
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.310
- NOTCH_SIGNALING+0.270
- BILE_ACID_METABOLISM+0.190
- UV_RESPONSE_DN+0.150
- MITOTIC_SPINDLE+0.130
- TGF_BETA_SIGNALING+0.090
- ESTROGEN_RESPONSE_EARLY+0.050
- SPERMATOGENESIS+0.040
- DNA_REPAIR+0.020
- PEROXISOME+0.000
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.560
- INFLAMMATORY_RESPONSE-0.520
- INTERFERON_GAMMA_RESPONSE-0.510
- ALLOGRAFT_REJECTION-0.500
- INTERFERON_ALPHA_RESPONSE-0.470
- TNFA_SIGNALING_VIA_NFKB-0.470
- IL2_STAT5_SIGNALING-0.420
- COMPLEMENT-0.400
- MTORC1_SIGNALING-0.400
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.390
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | s0102877 | — | — | 0.903 |
| 2 | MBCProject_0226_T1_RNA | — | A | 0.881 |
| 3 | SRR650167 | — | — | 0.868 |
| 4 | MBCProject_0719_T1_RNA | — | A | 0.866 |
| 5 | SRR8518450 | — | A | 0.857 |
| 6 | MNG660 | — | — | 0.851 |
| 7 | TCGA-OR-A5L8-01 | Adrenocortical Carcinoma | Adrenocortical Carcinoma, Usual Type | 0.851 |
| 8 | TCGA-A7-A4SB-01A-21R-A266-07 | — | B | 0.849 |
| 9 | TCGA-55-A494-01A-11R-A24X-07 | — | cohortA3 | 0.849 |
| 10 | 302722c6-102e-4b1b-845e-78920380e337 | — | — | 0.848 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.310 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.270 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.150 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.130 | Inavolisib | — uncovered |
| TGF_BETA_SIGNALING | 0.090 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.050 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.040 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.020 | Idelalisib | — uncovered |