SRR650167
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MITOTIC_SPINDLE+0.120
- NOTCH_SIGNALING+0.090
- DNA_REPAIR+0.060
- SPERMATOGENESIS+0.060
- MYC_TARGETS_V2+0.000
- GLYCOLYSIS-0.040
- PROTEIN_SECRETION-0.040
- ESTROGEN_RESPONSE_EARLY-0.060
- P53_PATHWAY-0.060
- MYC_TARGETS_V1-0.070
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.590
- ALLOGRAFT_REJECTION-0.540
- IL6_JAK_STAT3_SIGNALING-0.540
- INFLAMMATORY_RESPONSE-0.500
- INTERFERON_GAMMA_RESPONSE-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.470
- INTERFERON_ALPHA_RESPONSE-0.460
- COMPLEMENT-0.440
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.410
- IL2_STAT5_SIGNALING-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1364800 | GTEX | — | 0.919 |
| 2 | SRR607967 | GTEX | — | 0.911 |
| 3 | SRR8613756 | — | E | 0.909 |
| 4 | SRR1441224 | GTEX | — | 0.908 |
| 5 | SRR650132 | — | — | 0.908 |
| 6 | SRR1324452 | GTEX | — | 0.907 |
| 7 | SRR1459033 | GTEX | — | 0.906 |
| 8 | SRR1322010 | GTEX | — | 0.905 |
| 9 | MDT-AP-0189 | Med | Medulloblastoma | 0.905 |
| 10 | SRR1433644 | GTEX | — | 0.904 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MITOTIC_SPINDLE | 0.120 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.090 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.060 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |