Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934895

0185e736-8b6e-51b9-b37d-f4d84d0ffc4c

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Female

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934942
brain-umap@2
0.974
2SRR934925
brain-umap@2
0.958
3SRR934907
brain-umap@2
0.952
4SRR934802
brain-umap@2
0.950
5SRR934936
brain-umap@2
0.940
6SRR934875
brain-umap@2
0.938
7SRR934871
brain-umap@2
0.936
842B7A295-5E3D-44DA-B93F-40E64A551364
brain-umap@2
0.936
9BS_0WQJP6ZG
brain-umap@2
Supratentorial Ependymoma0.935
10SRR934825
brain-umap@2
0.934

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 39 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.518Remibrutinib— uncovered
TGF_BETA_SIGNALING0.494Inavolisib— uncovered
G2M_CHECKPOINT0.491Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.466Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.440Idelalisib— uncovered
INTERFERON_ALPHA_RESPONSE0.437Inavolisib— uncovered
MITOTIC_SPINDLE0.429Inavolisib— uncovered
E2F_TARGETS0.407Inavolisib— uncovered
ALLOGRAFT_REJECTION0.388Idelalisib— uncovered
ANDROGEN_RESPONSE0.378Inavolisib— uncovered
MYC_TARGETS_V10.377Inavolisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.371Idelalisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.349Inavolisib— uncovered
COMPLEMENT0.348Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.347Idelalisib— uncovered
MTORC1_SIGNALING0.340Inavolisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.311Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.300Inavolisib— uncovered
APOPTOSIS0.287Idelalisib— uncovered
REACTIVE_OXYGEN_SPECIES_PATHWAY0.285Inavolisib— uncovered