Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934802

675331db-1fbc-5857-be0e-de348b2ae578

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
8.639947437582128
age_years
63
sex
Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • INTERFERON_ALPHA_RESPONSE+0.757
  • INTERFERON_GAMMA_RESPONSE+0.661
  • E2F_TARGETS+0.593
  • G2M_CHECKPOINT+0.569
  • ALLOGRAFT_REJECTION+0.562
  • IL6_JAK_STAT3_SIGNALING+0.531
  • MYC_TARGETS_V1+0.510
  • PROTEIN_SECRETION+0.462
  • INFLAMMATORY_RESPONSE+0.439
  • TGF_BETA_SIGNALING+0.431

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.389
  • PANCREAS_BETA_CELLS-0.385
  • MYOGENESIS-0.175
  • SPERMATOGENESIS-0.139
  • OXIDATIVE_PHOSPHORYLATION-0.088
  • ESTROGEN_RESPONSE_EARLY-0.081
  • WNT_BETA_CATENIN_SIGNALING-0.060
  • ESTROGEN_RESPONSE_LATE-0.044
  • APICAL_SURFACE-0.021
  • BILE_ACID_METABOLISM-0.020

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR934925
brain-umap@2
0.967
262966348-1C16-4A6D-AA82-707B3F759D5C
brain-umap@2
0.963
3SRR934753
brain-umap@2
0.961
48B4E465B-0FD5-4154-824B-1E6B2656FD2F
brain-umap@2
0.955
5SRR934730
brain-umap@2
0.954
6SRR934722
brain-umap@2
0.954
7SRR934895
brain-umap@2
0.950
8SRR934837
brain-umap@2
0.947
9SRR934737
brain-umap@2
0.945
10SRR934932
brain-umap@2
0.944

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 40 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
INTERFERON_ALPHA_RESPONSE0.757Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.661Idelalisib— uncovered
E2F_TARGETS0.593Inavolisib— uncovered
G2M_CHECKPOINT0.569Inavolisib— uncovered
ALLOGRAFT_REJECTION0.562Idelalisib— uncovered
IL6_JAK_STAT3_SIGNALING0.531Inavolisib— uncovered
MYC_TARGETS_V10.510Inavolisib— uncovered
PROTEIN_SECRETION0.462Remibrutinib— uncovered
INFLAMMATORY_RESPONSE0.439Idelalisib— uncovered
TGF_BETA_SIGNALING0.431Inavolisib— uncovered
MTORC1_SIGNALING0.423Inavolisib— uncovered
APOPTOSIS0.411Idelalisib— uncovered
MYC_TARGETS_V20.411Idelalisib— uncovered
MITOTIC_SPINDLE0.398Inavolisib— uncovered
COMPLEMENT0.393Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.391Inavolisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.382Inavolisib— uncovered
IL2_STAT5_SIGNALING0.378Idelalisib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.369Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.358Inavolisib— uncovered