SRR655218
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.425
- SPERMATOGENESIS+0.231
- HEDGEHOG_SIGNALING+0.188
- MTORC1_SIGNALING+0.162
- UV_RESPONSE_DN+0.135
- OXIDATIVE_PHOSPHORYLATION+0.094
- HEME_METABOLISM+0.092
- ANDROGEN_RESPONSE+0.083
- PEROXISOME+0.060
- ADIPOGENESIS+0.056
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.412
- ANGIOGENESIS-0.394
- ALLOGRAFT_REJECTION-0.374
- IL6_JAK_STAT3_SIGNALING-0.373
- COAGULATION-0.347
- INFLAMMATORY_RESPONSE-0.337
- INTERFERON_ALPHA_RESPONSE-0.329
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.320
- INTERFERON_GAMMA_RESPONSE-0.304
- TGF_BETA_SIGNALING-0.298
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR661973 | GTEX | — | 0.914 |
| 2 | SRR658129 | GTEX | — | 0.896 |
| 3 | SRR655649 | GTEX | — | 0.891 |
| 4 | SRR657754 | GTEX | — | 0.891 |
| 5 | SRR659484 | GTEX | — | 0.890 |
| 6 | SRR661445 | GTEX | — | 0.885 |
| 7 | SRR35579848 | — | B | 0.876 |
| 8 | SRR2167030 | GTEX | — | 0.870 |
| 9 | SRR820623 | GTEX | — | 0.865 |
| 10 | MBCProject_0343_T1_RNA | — | B | 0.863 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.425 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.231 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.188 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.162 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.135 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.094 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.092 | Temsirolimus | — uncovered |
| ANDROGEN_RESPONSE | 0.083 | Inavolisib | — uncovered |
| PEROXISOME | 0.060 | Idelalisib | — uncovered |
| ADIPOGENESIS | 0.056 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.056 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.009 | Idelalisib | — uncovered |