SRR659484
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.242
- SPERMATOGENESIS+0.237
- HEME_METABOLISM+0.139
- HEDGEHOG_SIGNALING+0.114
- FATTY_ACID_METABOLISM+0.093
- UV_RESPONSE_DN+0.088
- OXIDATIVE_PHOSPHORYLATION+0.030
- BILE_ACID_METABOLISM+0.015
- PEROXISOME+0.007
- MITOTIC_SPINDLE-0.007
Top 10 suppressed
- ANGIOGENESIS-0.451
- ALLOGRAFT_REJECTION-0.410
- INFLAMMATORY_RESPONSE-0.404
- NOTCH_SIGNALING-0.395
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.384
- TNFA_SIGNALING_VIA_NFKB-0.358
- IL6_JAK_STAT3_SIGNALING-0.357
- APOPTOSIS-0.331
- CHOLESTEROL_HOMEOSTASIS-0.324
- APICAL_SURFACE-0.316
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR655649 | GTEX | — | 0.954 |
| 2 | SRR11296802 | — | — | 0.914 |
| 3 | SRR661973 | GTEX | — | 0.899 |
| 4 | SRR659555 | GTEX | — | 0.891 |
| 5 | SRR655218 | GTEX | — | 0.890 |
| 6 | SRR657754 | GTEX | — | 0.881 |
| 7 | SRR658129 | GTEX | — | 0.871 |
| 8 | SRR656745 | GTEX | — | 0.861 |
| 9 | MDT-AP-3207 | Med | Medulloblastoma | 0.861 |
| 10 | TCGA-A7-A13G-01A-11R-A13Q-07 | — | D | 0.859 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.242 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.237 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.139 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.114 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.093 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.088 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.030 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.015 | Inavolisib | — uncovered |
| PEROXISOME | 0.007 | Idelalisib | — uncovered |