SRR1431366
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.209
- SPERMATOGENESIS+0.090
- PI3K_AKT_MTOR_SIGNALING-0.006
- MITOTIC_SPINDLE-0.032
- UNFOLDED_PROTEIN_RESPONSE-0.061
- DNA_REPAIR-0.063
- PANCREAS_BETA_CELLS-0.064
- MYC_TARGETS_V2-0.066
- E2F_TARGETS-0.069
- APICAL_JUNCTION-0.095
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.572
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.486
- INTERFERON_GAMMA_RESPONSE-0.477
- TGF_BETA_SIGNALING-0.439
- ANGIOGENESIS-0.430
- INFLAMMATORY_RESPONSE-0.427
- APOPTOSIS-0.396
- CHOLESTEROL_HOMEOSTASIS-0.396
- COMPLEMENT-0.396
- COAGULATION-0.384
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1348021 | GTEX | — | 0.991 |
| 2 | SRR1439850 | GTEX | — | 0.984 |
| 3 | SRR1465132 | GTEX | — | 0.981 |
| 4 | SRR1402513 | GTEX | — | 0.978 |
| 5 | SRR1434271 | GTEX | — | 0.978 |
| 6 | SRR1429935 | GTEX | — | 0.977 |
| 7 | SRR1324452 | GTEX | — | 0.977 |
| 8 | SRR1338323 | GTEX | — | 0.975 |
| 9 | SRR1338669 | GTEX | — | 0.973 |
| 10 | SRR1384234 | GTEX | — | 0.973 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 2 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.209 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.090 | Inavolisib | — uncovered |